Among them are Yervoy (ipilimumab), which targets the protein CTLA-4 and is approved for the treatment of metastatic melanoma. Keytruda (pembrolizumab) inhibits the activity of the protein PD-1 and is approved for the treatment of unresectable or metastatic melanoma that has progressed on Yervoy and, if applicable, on a BRAF inhibitor.
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